Merge pull request #2105 from cBioPortal/target-rel

TARGET-GDC Initial Data Release

crdc/README.md

@@ -12,6 +12,7 @@ Supported programs:
 
 - [TCGA](https://www.cancer.gov/ccg/research/genome-sequencing/tcga)
 - [CPTAC](https://gdc.cancer.gov/about-gdc/contributed-genomic-data-cancer-research/clinical-proteomic-tumor-analysis-consortium-cptac)
+- [TARGET](https://www.cancer.gov/ccg/research/genome-sequencing/target)
 
 ### TCGA
 
@@ -73,3 +74,18 @@ Supported programs:
 - [`pancreas_cptac_gdc`](https://www.cbioportal.org/study/summary?id=pancreas_cptac_gdc): [Pancreatic Cancer](https://portal.gdc.cancer.gov/repository?facetTab=files&filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.primary_site%22%2C%22value%22%3A%5B%22pancreas%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22CPTAC%22%5D%7D%7D%5D%7D)
 - [`rcc_cptac_gdc`](https://www.cbioportal.org/study/summary?id=rcc_cptac_gdc): [Renal Cell Carcinoma](https://portal.gdc.cancer.gov/repository?facetTab=cases&filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.disease_type%22%2C%22value%22%3A%5B%22Adenomas%20and%20Adenocarcinomas%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.primary_site%22%2C%22value%22%3A%5B%22Kidney%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22CPTAC%22%5D%7D%7D%5D%7D)
 - [`uec_cptac_gdc`](https://www.cbioportal.org/study/summary?id=uec_cptac_gdc): [Uterine Endometrioid Carcinoma](https://portal.gdc.cancer.gov/repository?facetTab=cases&filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.disease_type%22%2C%22value%22%3A%5B%22Adenomas%20and%20Adenocarcinomas%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.primary_site%22%2C%22value%22%3A%5B%22Uterus%2C%20NOS%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22CPTAC%22%5D%7D%7D%5D%7D)
+
+### TARGET
+
+- **Cancer type mapping:** Each study corresponds to one or more TARGET projects. The TARGET project suffix is converted to an OncoTree code, which is used for the name of the study.
+    - **Example:** For the TARGET project `TARGET-ALL-P2`, the `ALL-P2` suffix is taken and converted to the OncoTree code `BLL`. The resulting cBioPortal study is `bll_target_gdc`.
+    - [Mapping file](https://github.com/cBioPortal/nci-crdc-pipeline/blob/main/resources/oncotree_mappings/target.txt)
+
+#### List of TARGET cBioPortal Studies
+
+- [`alal_target_gdc`](https://www.cbioportal.org/study/summary?id=alal_target_gdc): TARGET-ALL-P3, [Acute Lymphoblastic Leukemia - Phase III](https://portal.gdc.cancer.gov/projects/TARGET-ALL-P3)
+- [`aml_target_gdc`](https://www.cbioportal.org/study/summary?id=aml_target_gdc): TARGET-AML, [Acute Myeloid Leukemia](https://portal.gdc.cancer.gov/projects/TARGET-AML)
+- [`bll_target_gdc`](https://www.cbioportal.org/study/summary?id=bll_target_gdc): TARGET-ALL-P2, [Acute Lymphoblastic Leukemia - Phase II](https://portal.gdc.cancer.gov/projects/TARGET-ALL-P2)
+- [`nbl_target_gdc`](https://www.cbioportal.org/study/summary?id=nbl_target_gdc): TARGET-NBL, [Neuroblastoma](https://portal.gdc.cancer.gov/projects/TARGET-NBL)
+- [`os_target_gdc`](https://www.cbioportal.org/study/summary?id=os_target_gdc): TARGET-OS, [Osteosarcoma](https://portal.gdc.cancer.gov/projects/TARGET-OS)
+- [`wt_target_gdc`](https://www.cbioportal.org/study/summary?id=wt_target_gdc): TARGET-WT, [Wilms' Tumor](https://portal.gdc.cancer.gov/projects/TARGET-WT)

crdc/gdc/alal_target_gdc/README.md

@@ -0,0 +1,152 @@
+# Comments & assumptions made during curation
+
+## General
+
+- Study is updated once every 3 months with latest data from [ISB-CGC BigQuery tables](https://isb-cgc.appspot.com/bq_meta_search/)
+  - The ISB-CGC tables allow easy access to data collected from multiple NCI-CRDC repositories including the GDC, PDC, and others. The TARGET data in this study comes from the GDC and is accessed through these tables.
+- Reference genome used: hg38
+- TARGET started using the hg38 genome as of GDC release 32. For more information, refer to the [GDC release notes](https://docs.gdc.cancer.gov/Data/Release_Notes/Data_Release_Notes/#data-release-320).
+
+- Only tumor sample data is included (no normal samples)
+- [GDC project webpage](https://portal.gdc.cancer.gov/projects/TARGET-ALL-P3)
+
+## Clinical data
+
+- **Patient data:** Retrieved from `isb-cgc-bq.TARGET_versioned.clinical_gdc_r40`. ISB-CGC data was created in April 2024.
+- **Sample data:** Retrieved from `isb-cgc-bq.TARGET_versioned.per_sample_file_metadata_hg38_gdc_r40`. ISB-CGC data was created in April 2024.
+
+### Survival data
+
+Survival fields are calculated from the clinical data and added as new columns in the clinical file.
+
+- `OS_STATUS` is converted from `demo__vital_status`
+- `OS_MONTHS` is converted from `demo__days_to_death`, falls back to `diag__days_to_last_follow_up`
+
+
+
+
+### Timeline data
+
+- Timeline data is extracted from the clinical data and stored in separate data files. After extraction, the corresponding BigQuery fields are removed from the clinical file. For example, a timeline status of `DEATH` corresponds to the BigQuery field `demo__days_to_death`.
+
+#### Patient status data
+
+- For TARGET, the "time 0" anchor point is always the date of diagnosis. Not all patients have timeline data available, as indicated by a null `diag__days_to_diagnosis` (TCGA) or `index_date` (CPTAC, TARGET) field.
+
+- Birth timeline events are removed, as they (1) push other events to the far right of the graph and (2) can potentially be used to identify the patient.
+
+The following status values are supported in `data_timeline_status.txt`:
+
+- (time 0) → `Initial Diagnosis`
+- `demo__days_to_death` → `DECEASED`
+- `diag__days_to_last_follow_up` → `Last Follow Up`
+### Other transformations
+
+- `"not reported"` values are replaced with blanks.
+- If a clinical field is missing for the entire study, the column is removed from the data file.
+- `RACE`, `ETHNICITY`, and `SEX` are capitalized.
+- `AGE` is converted from days to years. 
+
+## CNA data
+
+- Retrieved from `isb-cgc-bq.TARGET_versioned.copy_number_gene_level_hg38_gdc_r36`. ISB-CGC data was created in March 2023.
+- Transformations
+  - Copy number values from the BigQuery tables are converted from [ASCAT](https://www.pnas.org/doi/10.1073/pnas.1009843107https://www.pnas.org/doi/10.1073/pnas.1009843107) to GISTIC 2.0 using the following thresholds:
+
+| ASCAT Value | GISTIC Value | Meaning |
+|---|---|---|
+| X = 0 | -2 | Deep loss |
+| X = 1 | -1 | Single-copy loss |
+| X = 2 | 0 | Diploid |
+| 2 < X < 7 | 1 | Low-level gain |
+| 7 ≤ X | 2 | Amplification |
+
+Only amplifications (GISTIC = 2) and deep deletions (GISTIC = -2) are shown on the cBioPortal website. As a result these conversion thresholds affect how many samples show up in the CNA chart, which can be inconsistent with legacy versions of this study. We chose ASCAT ≥ 7 as the amplification threshold because it resulted in the least deviation from our legacy studies.
+
+
+
+## mRNA Expression data
+
+- Retrieved from `isb-cgc-bq.TARGET_versioned.RNAseq_hg38_gdc_r35`. ISB-CGC data was created in December 2022.
+- The `unstranded`, `tpm_unstranded`, and `fpkm_uq_unstranded` columns are pulled and each mapped to their own data file.
+  - The regular FPKM values are excluded because [FPKM-UQ provides a more stable metric](https://docs.gdc.cancer.gov/Data/Bioinformatics_Pipelines/Expression_mRNA_Pipeline/#upper-quartile-fpkm).
+- Transformations: see [Genomic data transformations](#genomic-data-transformations)
+
+
+
+## Mutation data
+
+- Retrieved from `isb-cgc-bq.TARGET_versioned.masked_somatic_mutation_hg38_gdc_r40`. ISB-CGC data was created in July 2024.
+- The MAF is annotated with Genome Nexus in order to avoid issues with the isoform mapping. Parameters used:
+  - Endpoint: https://grch38.genomenexus.org/
+  - Isoform override: mskcc
+  - Replace gene symbols and Entrez IDs
+  - Post interval size: 500
+- Mutation data may be missing for some samples-- this reflects a lack of data availability in ISB-CGC.
+
+## Expression data transformations (CNA / mRNA)
+
+- Ensembl gene IDs are mapped to Entrez IDs using the [Genome Nexus hg38 canonical transcript file](https://github.com/genome-nexus/genome-nexus-importer/blob/master/data/grch38_ensembl95/export/ensembl_biomart_canonical_transcripts_per_hgnc.txt). Any genes that cannot be converted using this file are dropped.
+  - Prior to conversion, we also filter out a small number of duplicate Ensembl genes. These genes have copies containing data for both the X and the Y chromosomes.
+- If a sample has multiple aliquots, it has to be condensed to 1 before it can imported into cBioPortal. This is done by choosing the aliquot ID with the highest sort value (eg. highest plate number), following [the same policy](https://broadinstitute.atlassian.net/wiki/spaces/GDAC/pages/844334036/FAQ#FAQ-replicateFilteringQ%3AWhatdoyoudowhenmultiplealiquotbarcodesexistforagivensample%2Fportion%2Fanalytecombination%3F) used by GDAC used to condense aliquot data in their studies.
+
+## Post-processing steps
+
+  - Samples that lack any genomic data are removed from the clinical sample file.
+  - Metadata headers are added to the clinical patient and sample files using a curation-provided script.
+  - TMB scores are calculated and added to the clinical sample file using a curation-provided script.
+  - Case lists are generated under `case_lists/` using a curation-provided script.
+  - The validator script is run and the HTML report is saved under `validation_reports/`.
+
+## List of remapped columns
+
+### Clinical patient
+
+| Original | cBioPortal |
+|---|---|
+| submitter_id | PATIENT_ID |
+| case_id | OTHER_PATIENT_ID |
+| demo__ethnicity | ETHNICITY |
+| demo__gender | SEX |
+| demo__race | RACE |
+| demo__vital_status | VITAL_STATUS |
+| diag__age_at_diagnosis | AGE |
+| diag__classification_of_tumor | TUMOR_CLASSIFICATION |
+| diag__cog_neuroblastoma_risk_group | COG_NEUROBLASTOMA_RISK_GROUP |
+| diag__icd_10_code | ICD_10 |
+| diag__inss_stage | INSS_STAGE |
+| diag__last_known_disease_status | DISEASE_STATUS |
+| diag__metastasis_at_diagnosis | METASTASIS_AT_DIAGNOSIS |
+| diag__morphology | MORPHOLOGY |
+| diag__path__necrosis_percent | PATHOLOGY_NECROSIS_PERCENT |
+| diag__primary_diagnosis | PRIMARY_DIAGNOSIS |
+| diag__site_of_resection_or_biopsy | BIOPSY_SITE |
+| diag__year_of_diagnosis | YEAR_OF_DIAGNOSIS |
+| disease_type | DISEASE_TYPE |
+| index_date | INDEX_DATE |
+| primary_site | PRIMARY_SITE_PATIENT |
+| proj__name | PROJECT_NAME |
+| proj__project_id | PROJECT_ID |
+
+
+### Clinical sample
+
+| Original | cBioPortal |
+|---|---|
+| case_barcode | PATIENT_ID |
+| sample_barcode | SAMPLE_ID |
+| sample_gdc_id | OTHER_SAMPLE_ID |
+| sample_type_name | SAMPLE_TYPE |
+| primary_site | PRIMARY_SITE |
+| days_to_collection | DAYS_TO_COLLECTION |
+| days_to_sample_procurement | DAYS_TO_SPECIMEN_COLLECTION |
+| is_ffpe | IS_FFPE |
+
+
+
+### Mutation
+
+| Original | cBioPortal |
+|---|---|
+| sample_barcode_tumor | Tumor_Sample_Barcode |
+| sample_barcode_normal | Matched_Norm_Sample_Barcode |

crdc/gdc/alal_target_gdc/case_lists/cases_all.txt

@@ -0,0 +1,6 @@
+cancer_study_identifier: alal_target_gdc
+stable_id: alal_target_gdc_all
+case_list_name: All samples
+case_list_description: All samples (233 samples)
+case_list_category: all_cases_in_study
+case_list_ids: TARGET-15-SJMPAL042796-09A	TARGET-15-SJMPAL016342-09B	TARGET-15-SJMPAL011914-09B	TARGET-15-SJMPAL042943-09A	TARGET-15-SJMPAL044948-09A	TARGET-15-SJMPAL046471-09A.1	TARGET-15-PASZVW-09B	TARGET-15-SJMPAL012419-09A	TARGET-15-SJMPAL046471-09A	TARGET-15-SJMPAL012426-09A.3	TARGET-15-SJMPAL041120-09A	TARGET-15-SJMPAL043770-09B	TARGET-15-SJMPAL040030-09A.1	TARGET-15-SJMPAL042789-09A.3	TARGET-15-SJMPAL043769-03B	TARGET-20-SJAML040268-09A	TARGET-20-SJAML045742-09A	TARGET-15-SJMPAL040030-09A.3	TARGET-15-SJMPAL012418-09A.2	TARGET-15-SJMPAL042795-09A.2	TARGET-15-SJMPAL044950-09A	TARGET-20-SJAML003320-09A	TARGET-15-SJMPAL041122-09A.1	TARGET-15-SJMPAL016343-09A.1	TARGET-15-SJMPAL040030-09A.4	TARGET-15-SJMPAL041119-09A.1	TARGET-20-SJAML016570-09A	TARGET-15-SJMPAL041119-09B	TARGET-15-SJMPAL012419-09B	TARGET-20-SJAML007113-09A	TARGET-15-SJMPAL044953-09A	TARGET-15-SJMPAL016343-09A	TARGET-15-SJMPAL012422-09A	TARGET-20-SJAML003322-09A	TARGET-15-SJMPAL016340-09A	TARGET-15-SJMPAL017981-03A	TARGET-15-SJMPAL011912-09A.1	TARGET-15-SJMPAL040036-03A.2	TARGET-15-SJMPAL017978-09A	TARGET-15-PARWPU-09A.1	TARGET-15-SJMPAL042799-09A	TARGET-15-SJMPAL040031-09A.2	TARGET-20-SJAML045741-09A	TARGET-15-SJMPAL046470-09A.1	TARGET-15-SJMPAL046467-09A	TARGET-15-SJMPAL040030-09A.2	TARGET-15-SJMPAL040037-09A.2	TARGET-15-SJMPAL043512-09B	TARGET-15-SJMPAL016342-09A.3	TARGET-15-SJMPAL012421-09B	TARGET-20-SJAML007112-09A	TARGET-15-SJMPAL040033-09A	TARGET-15-SJMPAL046468-09A	TARGET-15-SJMPAL040039-09A	TARGET-15-SJMPAL012422-09A.1	TARGET-15-SJMPAL040038-09A	TARGET-15-SJMPAL041117-09A	TARGET-15-SJMPAL046466-09A	TARGET-15-SJMPAL016342-09A.2	TARGET-15-SJMPAL041119-09A	TARGET-15-SJMPAL011912-09A	TARGET-15-SJMPAL040037-09A.1	TARGET-15-SJMPAL041122-09A.2	TARGET-15-SJMPAL046470-09A.2	TARGET-15-SJMPAL016344-09A	TARGET-15-SJMPAL042801-09A	TARGET-15-SJMPAL016447-09A.1	TARGET-15-SJMPAL041122-09A	TARGET-15-SJMPAL043505-09B	TARGET-15-SJMPAL042795-09A.3	TARGET-15-SJMPAL016343-09A.3	TARGET-20-SJAML045740-09A	TARGET-15-PAVFTF-09B	TARGET-15-SJMPAL041117-09A.1	TARGET-15-SJMPAL040459-09B	TARGET-15-SJMPAL043508-09B	TARGET-15-SJMPAL041120-09B	TARGET-15-SJMPAL041118-09A.2	TARGET-15-SJMPAL042793-09A	TARGET-15-SJMPAL042792-09A.2	TARGET-15-SJMPAL043775-09B	TARGET-15-SJMPAL016447-09A	TARGET-15-SJMPAL017973-09A.2	TARGET-15-SJMPAL043514-09A	TARGET-15-SJMPAL044956-09A	TARGET-15-SJMPAL040027-09A.1	TARGET-15-SJMPAL046469-09A	TARGET-15-SJMPAL042789-09A.1	TARGET-15-SJMPAL041117-09B	TARGET-15-SJMPAL011913-09A	TARGET-20-SJAML045737-09A	TARGET-15-SJMPAL043511-09B	TARGET-15-SJMPAL017981-03A.2	TARGET-15-SJMPAL040034-09A	TARGET-15-SJMPAL011911-03A.1	TARGET-15-SJMPAL041117-09A.2	TARGET-15-SJMPAL040036-03A	TARGET-15-SJMPAL040031-09A.1	TARGET-15-SJMPAL043773-03B	TARGET-15-SJMPAL012425-09A.2	TARGET-15-SJMPAL017978-09A.2	TARGET-15-SJMPAL012420-09A	TARGET-15-SJMPAL040031-09A.4	TARGET-20-SJAML045736-09A	TARGET-15-SJMPAL042794-09A.3	TARGET-15-SJMLL003311-09A.2	TARGET-15-SJMPAL046466-09A.1	TARGET-15-SJMPAL042946-09A	TARGET-15-SJMPAL042794-09A	TARGET-15-SJMPAL043512-09A	TARGET-15-SJMPAL040027-09A.3	TARGET-15-SJMPAL040033-09A.2	TARGET-15-SJMPAL040036-03B	TARGET-15-SJMPAL040038-09B	TARGET-15-SJMPAL043771-09B	TARGET-15-SJMPAL041120-09A.1	TARGET-15-SJMPAL017973-09A.1	TARGET-15-SJMPAL042791-09B	TARGET-15-SJMPAL017976-09A.2	TARGET-15-SJMPAL040037-09A.4	TARGET-15-SJMPAL040033-09A.3	TARGET-15-PARWPU-09B	TARGET-15-SJMPAL044949-09A	TARGET-15-SJMPAL012422-09A.2	TARGET-15-SJMPAL012422-09A.3	TARGET-15-SJMPAL040025-09B	TARGET-15-SJMPAL041122-09A.3	TARGET-15-SJMLL003311-09A.1	TARGET-15-SJMPAL042789-09A.2	TARGET-15-SJMPAL041118-09A.1	TARGET-20-SJAML045735-09A	TARGET-15-SJMPAL042798-09A	TARGET-15-SJMPAL016447-09A.3	TARGET-15-SJMPAL017976-09A.3	TARGET-15-SJMPAL012418-09A.3	TARGET-15-SJMPAL012417-09A	TARGET-15-SJMPAL042787-09A.2	TARGET-15-SJMPAL040036-03A.3	TARGET-15-SJMPAL046471-09A.2	TARGET-15-SJMPAL042794-09A.2	TARGET-15-SJMPAL040037-09B	TARGET-15-SJMPAL043774-09B	TARGET-15-SJMPAL040025-09A.1	TARGET-15-SJMPAL017981-03A.3	TARGET-20-SJAML045734-09A	TARGET-15-SJMPAL042794-09B	TARGET-15-SJMPAL042941-09A.2	TARGET-15-SJMPAL040031-09A	TARGET-15-SJMPAL012426-09A.2	TARGET-15-SJMPAL042793-09B	TARGET-15-SJMPAL040031-09A.3	TARGET-15-SJMPAL043510-09A	TARGET-15-SJMPAL017981-03A.1	TARGET-15-PAREAT-09B	TARGET-15-SJMPAL016342-09A.1	TARGET-15-SJMPAL040025-09A.2	TARGET-15-SJMPAL042792-09A	TARGET-15-SJMPAL040039-09B	TARGET-15-SJMPAL040024-09A	TARGET-15-SJMPAL012426-09A.1	TARGET-15-SJMPAL040024-09A.1	TARGET-15-SJMPAL042792-09A.1	TARGET-15-PARWPU-09A	TARGET-15-SJMPAL042797-09A	TARGET-15-SJMPAL012424-03A.2	TARGET-15-SJMPAL017975-03A.1	TARGET-15-SJMPAL040035-03A	TARGET-15-SJMPAL011914-09A	TARGET-15-SJMPAL040459-09A	TARGET-15-SJMPAL017977-09A	TARGET-15-SJMPAL017978-09A.1	TARGET-15-SJMPAL044957-09A	TARGET-15-SJMPAL017975-03B	TARGET-15-SJMPAL040026-09A	TARGET-15-SJMPAL046470-09A	TARGET-15-SJMPAL042801-09B	TARGET-15-SJMPAL042792-09A.3	TARGET-15-SJMPAL042794-09A.1	TARGET-15-SJMPAL011915-09A	TARGET-15-SJMPAL040038-09A.1	TARGET-15-SJMPAL040032-09A.1	TARGET-15-SJMPAL017975-03A.2	TARGET-20-SJAML045738-09A	TARGET-15-SJMPAL017973-09A	TARGET-15-SJMPAL022667-09A	TARGET-15-SJMPAL042791-09A	TARGET-15-SJMPAL042787-09B	TARGET-15-SJMPAL040033-09A.1	TARGET-15-SJMPAL041118-09A.3	TARGET-15-SJMPAL046466-09A.2	TARGET-15-SJMPAL042787-09A.1	TARGET-15-SJMPAL012425-09A.1	TARGET-15-SJMPAL012425-09A	TARGET-15-SJMPAL012420-09A.1	TARGET-15-SJMPAL016342-09A	TARGET-15-SJMPAL016343-09A.2	TARGET-15-SJMPAL040027-09A	TARGET-15-SJMPAL040036-03A.1	TARGET-15-SJMPAL042798-09B	TARGET-15-SJMPAL016448-09A	TARGET-15-SJMPAL043768-09B	TARGET-15-SJMPAL011911-03A	TARGET-15-SJMPAL017976-09A.1	TARGET-15-SJMPAL040039-09A.2	TARGET-15-SJMPAL040039-09A.1	TARGET-15-SJMPAL042795-09A.1	TARGET-15-PAUFIB-09B	TARGET-15-SJMPAL012424-03A.1	TARGET-15-SJMPAL041118-09A	TARGET-15-SJMPAL042799-09B	TARGET-15-SJMPAL041119-09A.2	TARGET-15-SJMPAL040025-09A	TARGET-15-PARWPU-09A.2	TARGET-15-SJMPAL040030-09A	TARGET-15-SJMPAL012418-09A	TARGET-15-SJMPAL043773-40A	TARGET-15-SJMPAL012419-09A.1	TARGET-15-SJMPAL040024-09A.2	TARGET-15-SJMPAL040036-03A.4	TARGET-15-SJMPAL012420-09A.2	TARGET-15-SJMPAL043767-09B	TARGET-15-SJMPAL042787-09A	TARGET-15-PARWPU-09A.3	TARGET-15-SJMPAL012418-09A.1	TARGET-15-SJMPAL040037-09A	TARGET-15-SJMPAL042946-09B	TARGET-15-SJMPAL017978-09A.3	TARGET-15-SJMPAL017975-03A	TARGET-15-SJMPAL046468-09A.1	TARGET-15-SJMPAL016447-09A.2	TARGET-15-SJMPAL046472-09A	TARGET-15-SJMPAL040027-09A.2	TARGET-20-SJAML045739-09A