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v4.0.0 - fragment based counting

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@keiranmraine keiranmraine released this 06 Mar 11:23
· 62 commits to dev since this release
77ee1f1
  • alleleCounter now counts per-fragment rather than per-read when overlaps occur.
    1. When members of a pair overlap and calls match the depth and allele seen are only counted once.
    2. When mate reads disagree on the call, the depth is counted as 2 and both allele counts incremented.
  • Reworked perl to wrap C alleleCounter and just handle the extra format changes.
  • Removed dependency on Bio::DB::HTS.
  • Update to HTSlib 1.7
  • Merged #43, providing 10X processing mode.