Code for "Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines"
This repository provides tools for modeling the production of antibodies using measures of Memory B Cell and plasmablasts concentrations, and sVNT titres for SARS-CoV-2, as outlined in "Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines" preprinted at XX.
This repository is not a package, but the data and all functions necessary to run the code can loaded by running the "R/main.R" file.
A guide on how to recreate the analysis in the preprint for "Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines" is given in vignettes/workflow.Rmd
We welcome contributions to the package or if they wish to use this model on another dataset. To contribute, follow these steps:
- Fork the repository.
- Create a new branch (
git checkout -b feature-branch). - Make your changes.
- Commit your changes (
git commit -m 'Add some feature'). - Push to the branch (
git push origin feature-branch). - Open a pull request.
This project is licensed under the MIT License - see the LICENSE file for details.
David Hodgson - david.hodgson@lshtm.ac.uk