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US 21J Delta sublineage with S:675H (~1%, 4k seq, daily growth advantage ~1%) #288

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corneliusroemer opened this issue Oct 22, 2021 · 2 comments
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@corneliusroemer
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New lineage proposal
by @corneliusroemer

Description
Sub-lineage of: B.1.617.2 (21J)
Earliest sequence: 2021-24 US
Most recent sequence: Current
Countries circulating: ~1% in US

Lineage was spotted because it has substitution S:675H, which is the site that is also substituted in #284 (although there the sub is to K). It seems to have a pretty steady growth trajectory, albeit only with ~15

It also has mutation 8829T which can be used to distinguish from other S:675H (there's apparently one in Luxembourg that's unrelated).

image

https://cov-spectrum-develop-git-lapis-and-refactoring-cov-spectrum.vercel.app/explore/World/AllSamples/Past6M/variants/international-comparison?aaMutations=S%3A675H&nucMutations=8829T&pangoLineage=B.1.617.2*

image

https://nextstrain.org/groups/neherlab/ncov/na-usa?c=gt-S_675

Country Total Variant Sequences First seq. found at Last seq. found at
United States 3803 2021-24 2021-41
Sweden 30 2021-25 2021-30
Mexico 1 2021-29 2021-29
Canada 60 2021-30 2021-36
Argentina 1 2021-30 2021-30
Brazil 1 2021-31 2021-31
Israel 3 2021-31 2021-32
South Korea 1 2021-33 2021-33
Sint Maarten 5 2021-33 2021-33
Japan 1 2021-34 2021-34
United Kingdom 7 2021-35 2021-39
France 16 2021-36 2021-40
Germany 3 2021-38 2021-38
Greece 3 2021-38 2021-38
@c19850727
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Hi @corneliusroemer have you checked this sublineage recently?
there're ~5.8k sequences now and still showing a ~3% transmission advantage as per Cov-spectrum.
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@chrisruis
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Thanks @corneliusroemer This is a sublineage of AY.119 and we've added this as AY.119.2 in v1.2.110 to start on the branch with G23587C (S:Q675H)

@chrisruis chrisruis added this to the AY.119.2 milestone Dec 10, 2021
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