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Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis.

This repository contains the code to analyze the data from the manuscript.

DOI

Contents

  • src: Code for the analyses of FACS-based and Perturb-seq CRISPR screens. This folder contains a separate README file describing how to run the code.
  • metadata: Tables and annotations required for the analysis.
  • lockfiles: archived renv lockfiles
  • misc: archived scripts not required for the analysis
  • ATAC_ChIP: Code to analyze epigenomics datasets. This folder contains a separate README file that describes how to run the code.
  • CRISPR: Code to generate count matrices from FACS based CRISPR datasets. This folder contains a separate README file that describes how to run the code.
  • cellRanger: Code to generate CellRanger's output from Perturb-seq data. This folder contains a separate README file that describes how to run the code.