Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis.

This repository contains the code to analyze the data from the manuscript.

Contents

• src: Code for the analyses of FACS-based and Perturb-seq CRISPR screens. This folder contains a separate README file describing how to run the code.
• metadata: Tables and annotations required for the analysis.
• lockfiles: archived renv lockfiles
• misc: archived scripts not required for the analysis
• ATAC_ChIP: Code to analyze epigenomics datasets. This folder contains a separate README file that describes how to run the code.
• CRISPR: Code to generate count matrices from FACS based CRISPR datasets. This folder contains a separate README file that describes how to run the code.
• cellRanger: Code to generate CellRanger's output from Perturb-seq data. This folder contains a separate README file that describes how to run the code.