The scripts in this repository perform the following tasks necessary for the drug repositioning steps using Open Targets performed in the manuscript "Drug repositioning for psychiatric and neurological disorders through a network medicine approach":
01 - search Open Targets for every gene associated to a list of diseases (here: PNDs - Psychiatric and Neurological Disorders);
02 - search Open Targets for every drug associated to a list of diseases (here: PNDs - Psychiatric and Neurological Disorders);
03 - detect genes that are exclusive to each diseases;
04 - search Open Targets for drugs that affect the disease-exclusive genes detected in 03;
05 - filter results from 04 to keep only drugs that:
a) affect genes that are coexpressed in the group of diseases (here: genes coexpressed in PNDs according to Gandal, 2018a);
b) are not present in network 02;
c) affect only one gene among all searched genes;
06 - produce a drug-gene-disease table to be used for drug prioritization for repositioning in PNDs.
Authors: Thomaz Lüscher Dias, Helena Paula Brentani, Viviane Schuch, Patrícia Cristina Baleeiro Beltrão Braga, Daniel Martins-de-Souza, Glória Regina Franco, Helder Imoto Nakaya
Manuscript submitted to Translational Psychiatry. In review.