Update content/07.pathogenesis.md

Co-authored-by: Anthony Gitter <agitter@users.noreply.github.com>
greenelab · Mar 22, 2021 · a1050f1 · a1050f1
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@@ -459,7 +459,7 @@ Several studies used phylogenetic analysis to determine the source of local COVI
 There is an ongoing effort to collect SARS-CoV-2 genomes throughout the COVID-19 outbreak, and as of January 18, 2021 more than 381,000 genome sequences have been collected from patients.<!-- TODO: consider auto-updating this -->
 The sequencing data can be found at GISAID [@https://www.gisaid.org/], NCBI [@https://www.ncbi.nlm.nih.gov/sars-cov-2/], and COVID-19 data portal [@https://www.covid19dataportal.org/].
 
-While the evolution of SARS-CoV-2 variants are discussed elsewhere within this special issue [], some of these variants may be associated with increased transmission of SARS-CoV-2. 
+Some SARS-CoV-2 variants, which we review in more detail separately [@individual-evolution], may be associated with increased transmission of SARS-CoV-2. 
 For example, coordinated sequencing efforts of SARS-CoV-2 genomes in the U.K. were instrumental in detecting B.1.1.7/VOC 202012/01, a variant of concern (VOC) that, with an estimated R~0~ of 1.4, is associated with approximately 50% increased transmission due to genetic mutations in the _Spike_ gene that modify the Spike protein [@url:https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/955239/NERVTAG_paper_on_variant_of_concern__VOC__B.1.1.7.pdf; @doi:10.1101/2020.12.24.20248822; @doi:10.1016/j.cell.2021.01.044].<!--TO DO: What is the molecular rationale for why this is more virulent?-->
 This variant has now spread to at least 93 other countries [@url:https://cov-lineages.org/global_report_B.1.1.7.html], and other studies investigating its transmission have occurred.
 In the U.S. between December 2020 and January 2021, it was estimated that B.1.1.7 had an increased transmission of 35-45% relative to common SARS-CoV-2 variants at the time, and B.1.1.7 is now on its way to becoming the dominant SARS-CoV-2 variant in the U.S. [@doi:10.1101/2021.02.06.21251159].