Proposed abstract & title for pathogenesis manuscript

content/07.pathogenesis.md

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-## Pathogenesis and Transmission
+## Genomic and Viral Structure of SARS-CoV-2 in the Context of Pathogenesis, Symptomology, and Transmission
 
 ### Abstract
 
+The novel coronavirus SARS-CoV-2, which emerged in late 2019, has been a major force shaping the year 2020 as it spread around the world infecting tens of millions of people with coronavirus disease 2019 (COVID-19).
+While the viral species was unknown prior to January 2020, its similarity to other coronaviruses that infect humans has allowed for rapid insight into the mechanisms that it uses to infect human hosts, as well as the ways in which the human immune system can respond.
+Here, we contextualize SARS-CoV-2 among other coronaviruses and identify what is known and what can be inferred about its behavior once inside a human host.
+Because the genomic content of coronaviruses is highly conserved and specifies the virus's structure, early genomic analysis provided a significant head start in predicting viral pathogenesis.
+The pathogenesis of the virus offers insights into symptomology, transmission, and individual susceptibility.
+Additionally, prior research into interactions between the human immune system and coronaviruses identifies how these viruses can evade destruction.
+We also explore systems-level research into the regulatory and proteomic effects of SARS-CoV-2 infection and the immune response.
+Understanding the structure and behavior of the virus serves to contextualize many facets of the COVID-19 pandemic and can influence on efforts to control the virus and treat the disease.
+
+### Importance
+
+COVID-19 involves a number of organ systems and can present with a wide range of symptoms.
+Understanding how the virus infects epithelial cells, however, serves to contextualize how these systems connect.
+Similarly, the modes of viral transmission have been under debate throughout much of 2020, yet the available research suggests that these patterns are very similar to those seen with the closely related viruses SARS-CoV-1 and possibly MERS-CoV.
+Exploring the structure, phylogeny, and pathogenesis of the virus therefore helps to guide interpretation of the broader impacts of the virus on the human body and on human populations.
+For this reason, an in-depth exploration of viral mechanisms is critical to a robust understanding of the COVID-19 pandemic. 
+
 ### Introduction
 
-On January 21, 2020, the World Health Organization (WHO) released its first report concerning what is now known as the Coronavirus Disease 2019 (COVID-19) [@url:https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf].
+On January 21, 2020, the World Health Organization (WHO) released its first report concerning what is now known as coronavirus disease 2019 (COVID-19) [@url:https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf].
 This infectious disease came to international attention on December 31, 2019 following an announcement by national officials in China describing 44 cases of a respiratory infection of unknown cause.
 The first known cases were located in Wuhan City within the Hubei province of China, but the disease spread rapidly throughout China and subsequently around the world.
 At the time of the WHO's first situation report [@url:https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf], 282 confirmed cases had been identified.