Rocksmith Toolkit wrapped in wineskin to work on macOS 64-bit (Catalina/Big Sur supported)
Also added gatekeeper fix since macOS invalidate .net executables signatures, use it for smooth start.
After install, you should allow such unsigned application to run, immediately after first open and getting above error, you must do the following: System Preferences => Security & Privacy => Tab "General" => Allow anyway
Warning! First run could be really really slow, please be patient.