PESCA (Proportion of population-specific and shared causal variants)

PESCA is a method to estimate proportions of population-specific and shared causal variants from GWAS summary statistics. Please see for details.

- We detest usage of our software or scientific outcome to promote racial discrimination.

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Releases

• version 0.3-beta

• version 0.2-beta

• version 0.1-beta

Reference

• "Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data." AJHG 2020

PESCA posterior probabilities for the 9 diseases and complex traits analyzed can be downloaded here.

See also

• "Population-specific causal disease effect sizes in functionally important regions impacted by selection." Nature Communications 2021

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Contact

• Huwenbo Shi: hshi_AT_hsph.harvard.edu
• Kathryn Burch: kathy.s.burch_AT_gmail.com