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@lehner-lab

Lehner Lab

Software developed by members of the Lehner lab at the Centre for Genomic Regulation (CRG)

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  1. DiMSum DiMSum Public

    An error model and pipeline for analyzing deep mutational scanning (DMS) data and diagnosing common experimental pathologies

    R 28 6

  2. doubledeepms doubledeepms Public

    Source code for fitting thermodynamic models (MoCHI), downstream analyses and to reproduce all figures in the following publication: Mapping the energetic and allosteric landscapes of protein bindi…

    R 19 1

  3. RDGVassociation RDGVassociation Public

    Script to (1) perform component extraction via ICA & VAE, (2) perform network analysis, and (3) replicate paper figures from manuscript. Pre-print on bioRxiv: https://www.biorxiv.org/content/10.110…

    R 3

  4. MoCHI MoCHI Public

    Neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data

    Python 42 4

  5. Stop_codon_readthrough Stop_codon_readthrough Public

    Source code for computational analyses and to reproduce all figures in the following publication: Genome-scale quantification and prediction of drug-induced readthrough of pathogenic premature term…

    2

  6. krasddpcams krasddpcams Public

    Source code for computational analyses and to reproduce all figures in the following publication: The energetic and allosteric landscape for KRAS inhibition (Weng C, Faure AJ & Lehner B, 2022)

    R 4

Repositories

Showing 10 of 42 repositories
  • domainome Public
    lehner-lab/domainome’s past year of commit activity
    5 MIT 0 1 0 Updated Dec 10, 2024
  • DiMSum Public

    An error model and pipeline for analyzing deep mutational scanning (DMS) data and diagnosing common experimental pathologies

    lehner-lab/DiMSum’s past year of commit activity
    R 28 MIT 6 3 0 Updated Dec 2, 2024
  • MoCHI Public

    Neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data

    lehner-lab/MoCHI’s past year of commit activity
    Python 42 MIT 4 0 0 Updated Dec 2, 2024
  • V2R_surfexp_rescue Public
    lehner-lab/V2R_surfexp_rescue’s past year of commit activity
    Jupyter Notebook 0 0 0 0 Updated Nov 29, 2024
  • mochims Public

    Source code for analyses and to reproduce all figures in the following publication: MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis and allostery from deep mutational scanning data (Faure AJ & Lehner B, 2024)

    lehner-lab/mochims’s past year of commit activity
    R 0 MIT 0 0 0 Updated Aug 9, 2024
  • amyloids_energy_modelling Public

    Energetic modelling of Amyloid beta nucleation

    lehner-lab/amyloids_energy_modelling’s past year of commit activity
    Jupyter Notebook 0 MIT 1 0 0 Updated Aug 9, 2024
  • combinatorialcores Public

    Source code for analyses and figure reproduction in "Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution", Escobedo et. al 2024

    lehner-lab/combinatorialcores’s past year of commit activity
    Jupyter Notebook 1 0 0 0 Updated Aug 1, 2024
  • archstabms Public

    Source code for analyses and to reproduce all figures in the following publication: The genetic architecture of protein stability (Faure AJ et al., 2024)

    lehner-lab/archstabms’s past year of commit activity
    R 3 MIT 0 1 0 Updated Jul 28, 2024
  • Stop_codon_readthrough Public

    Source code for computational analyses and to reproduce all figures in the following publication: Genome-scale quantification and prediction of drug-induced readthrough of pathogenic premature termination codons (Toledano I, Supek F & Lehner B, 2023)

    lehner-lab/Stop_codon_readthrough’s past year of commit activity
    2 MIT 0 0 0 Updated Jul 13, 2024
  • canya Public

    A hybrid neural network to predict nucleation propensity

    lehner-lab/canya’s past year of commit activity
    Python 1 MIT 0 0 0 Updated Jun 27, 2024
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