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Incorrect expasy rule #135

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Karl-Krauth opened this issue Dec 13, 2023 · 1 comment
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Incorrect expasy rule #135

Karl-Krauth opened this issue Dec 13, 2023 · 1 comment

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@Karl-Krauth
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This rule for thermolysin is incorrect:

'thermolysin': r'[^DE](?=[AFILMV])',

it should be: r'[^DE](?=[AFILMV][^P])'
If you check the summary of the cleavage rules here: https://web.expasy.org/peptide_cutter/peptidecutter_enzymes.html the [^P] condition isn't included but it's included in the text above it and also seems to be implemented in their perl script.

I haven't checked other enzymes but there might be similar errors there too.

levitsky added a commit that referenced this issue Dec 13, 2023
@levitsky
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levitsky commented Dec 13, 2023

Thank you for reporting. I made the change you proposed, seeing as the Proline effect is both mentioned in text and implemented in the tool itself.

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