big scape classes

BiG-SCAPE classes

By default, BiG-SCAPE will try to separate clusters into eight classes. This is done based on the product annotation from antiSMASH (see here). New labels introduced in antiSMASH 5 and 6 are annotated with a superscript.

The rules followed are currently:

antiSMASH annotation	BiG-SCAPE class
t1pks, T1PKS5	PKS I
transatpks, t2pks, t3pks, otherks, hglks, transAT-PKS5, transAT-PKS-like5, T2PKS5, T3PKS5, PKS-like5, hglE-KS5, prodigiosin and combinations of these with {t1pks, T1PKS5} or themselves	PKS other
nrps, NRPS5, NRPS-like5, thioamide-NRP5, NAPAA6	NRPS
lantipeptide, thiopeptide, bacteriocin, linaridin, cyanobactin, glycocin, LAP, lassopeptide, sactipeptide, bottromycin, head_to_tail, microcin, microviridin, proteusin, guanidinotides, lanthipeptide5, lipolanthine5, RaS-RiPP5, fungal-RiPP5, thioamitides5.1, lanthipeptide-class-i6, lanthipeptide-class-ii6, lanthipeptide-class-iii6, lanthipeptide-class-iv6, lanthipeptide-class-v6, ranthipeptide6, redox-cofactor6, RRE-containing6, epipeptide6, cyclic-lactone-autoinducer6, spliceotide6, crocagin and combinations of these	RiPPs
amglyccycl, oligosaccharide, cf_saccharide, saccharide5 and combinations of these	Saccharides
terpene	Terpene
any of {PKS I} + any of {NRPS}	PKS/NRPS Hybrids
acyl_amino_acids, arylpolyene, aminocoumarin, ectoine, butyrolactone, nucleoside, melanin, phosphoglycolipid, phenazine, phosphonate, other, cf_putative, resorcinol, indole, ladderane, PUFA, furan, hserlactone, fused, cf_fatty_acid, siderophore, blactam, fatty_acid5, PpyS-KS5, CDPS5, betalactone5, PBDE5, tropodithietic-acid5, NAGGN5, halogenated5, pyrrolidine6, mycosporine-like and any combined annotation	Others
*	< mix >

Hybrids

If the hybrids mode is enabled, some clusters could be analyzed in different classes (if those are valid classes):

If cluster is the PKS-NRP_Hybrids BiG-SCAPE class: the cluster will also be put in the NRPS class and one of the PKS classes (PKS I or PKS other). If the cluster contains the t1pks annotation, it will always be put on the PKS I class.

If the cluster is classified as Others and BiG-SCAPE detects that it's because of a multiple annotation (e.g. terpene-t1pks), BiG-SCAPE will also put the cluster in every different individual class.