When using outputtype = 'AFNI', interfaces.afni.preprocess.Copy will incorrectly add the -prefix flag to the 3dcopy command, like so: c = afni.Copy() c.inputs.in_file = 'bold1.nii.gz' c.inputs.out_file = 'testcopy' c.inputs.outputtype = 'AFNI' c.cmdline > '3dcopy -prefix testcopy bold1.nii.gz' To which AFNI will reply: Standard error: ++ 3dcopy: AFNI version=AFNI_2011_12_21_1014 (Sep 18 2014) [64-bit] *\* FATAL ERROR: unknown option: -prefix *\* Program compile date = Sep 18 2014 Return code: 1 Interface Copy failed to run.