Revise definition of kidney as per kidney expert community request #3046
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Are all those functions applicable to all species with kidneys? Given that cartilaginous fishes have kidneys I'm concerned at least about the inclusion of 'bone health'. If the production of the active form of vitamin D is not species specific then maybe this could be rephrased? |
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Exactly what I was wondering. I doubt that all of these functions are true
for all vertebrates.
…On Wed, Aug 30, 2023, 8:01 PM Sue Bello ***@***.***> wrote:
Are all those functions applicable to all species with kidneys? Given that
cartilaginous fishes have kidneys I'm concerned at least about the
inclusion of 'bone health'. If the production of the active form is not
species specific then maybe this could be rephrased?
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Looking at multiple resources I propose the following definition: "A paired organ of the urinary tract that is responsible for filtering blood (producing urine), regulating bodily fluid homeostasis, and maintaining electrolyte levels." Kimball's biology pages: 15.5B: Vertebrate Kidneys |
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@RDruzinsky @sbello Thank you for your comments. I dug into the literature rather heavily and the last part about "bone health was the only thing that I think needs to be changed to be more broadly applicable; otherwise all of the other parts apply to all including cartilaginous fishes. Proposed revision based on comments and literature: A paired organ of the urinary tract that produces urine and maintains bodily fluid homeostasis, blood pressure, pH levels, red blood cell production and skeleton mineralization. PMID: 35003210 Atake, O. J. & Eames, B. F. Mineralized Cartilage and Bone-Like Tissues in Chondrichthyans Offer Potential Insights Into the Evolution and Development of Mineralized Tissues in the Vertebrate Endoskeleton. Front Genet 12, 762042 (2021). Supriyati, H., Rakhmiyati, R. & Luthfi, M. J. Anatomical and Histological Study of Shark (Carcharhinus sorrah) Kidney. Biology, Medicine, & Natural Product Chemistry (2019). at https://api.semanticscholar.org/CorpusID:214636289 blood pressure across vertebrates wrt kidney: Kevin Schulte and others, The evolution of blood pressure and the rise of mankind, Nephrology Dialysis Transplantation, Volume 30, Issue 5, May 2015, Pages 713–723, https://doi.org/10.1093/ndt/gfu275 osmoregulation/body fluid homeostasis: Imaseki, I., Wakabayashi, M., Hara, Y., Watanabe, T., Takabe, S., Kakumura, K., Honda, Y., Ueda, K., Murakumo, K., Matsumoto, R., Matsumoto, Y., Nakamura, M., Takagi, W., Kuraku, S. & Hyodo, S. Comprehensive analysis of genes contributing to euryhalinity in the bull shark, Carcharhinus leucas; Na(+)-Cl(-) co-transporter is one of the key renal factors upregulated in acclimation to low-salinity environment. J Exp Biol 222, jeb201780 (2019). |
@emquardokus could you run this definition with Sanjay Jain MD, PhD? |
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Looks good to me. Thanks!
Robert E. Druzinsky, Ph.D.
Clinical Associate Professor Emeritus
Dept. of Oral Biology
College of Dentistry
University of Illinois at Chicago
801 S. Paulina
Chicago, IL 60612
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Website: www.peerj.com/RobertDruzinsky
…On Tue, Oct 31, 2023 at 10:50 AM Aleix Puig ***@***.***> wrote:
Proposed revision based on comments and literature: A paired organ of the
urinary tract that produces urine and maintains bodily fluid homeostasis,
blood pressure, pH levels, red blood cell production and skeleton
mineralization.
@emquardokus <https://github.com/emquardokus> could you run this
definition with Sanjay Jain MD, PhD?
@RDruzinsky <https://github.com/RDruzinsky> @sbello
<https://github.com/sbello> Are there any further concerns with the
revised definitions?
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@aleixpuigb Begin forwarded message: From: "Jain, Sanjay" sanjayjain@wustl.edu the definition below is fine Sanjay Jain MD, PhD |
Uberon term
kidney
UBERON:0002113
http://purl.obolibrary.org/obo/UBERON_0002113
Suggested revision of textual definition
Requested by Sanjay Jain MD, PhD (HuBMAP, KPMP) in response to being contacted by several researchers and colleagues about the current definition of kidney that appears on the HuBMAP website organ pages : https://portal.hubmapconsortium.org/organ/kidney that is directly coming from uberon “A paired organ of the urinary tract which has the production of urine as its primary function”.
Proposed revised definition approved by Sanjay Jain MD, PhD "A paired organ of the urinary tract that produces urine and maintains bodily fluid homeostasis, blood pressure, pH levels, red blood cell production and bone health."
Add reference source from the National Kidney Foundation: :
https://www.kidney.org/kidneydisease/top-5-jobs-kidneys-do
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