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IBD propagation of IBA to leaf nodes with conflicting qualifier #13

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mugitty opened this issue Nov 7, 2019 · 2 comments
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IBD propagation of IBA to leaf nodes with conflicting qualifier #13

mugitty opened this issue Nov 7, 2019 · 2 comments
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@mugitty
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mugitty commented Nov 7, 2019

PAINT Implementation for geneontology/paint#54

  1. When a leaf gene has an experimental annotation consistent with the ancestral IBD annotation (meaning IBD is to the same or more general term in the experimental annotation with identical qualifier), it will receive an IBA.
  2. When a leaf gene has an experimental annotation with a conflict NOT qualifier to the ancestral IBD annotation, it should not receive an IBA.
  3. When a leaf gene has an experimental annotation with a conflict “contribute_to” or “colocalized_to” qualifier to the ancestral IBD annotation, it will still receive an IBA for the moment. Meanwhile, there is an effort to clean up the experimental annotations that contain those two qualifiers in GO. Once they are fixed, the leaf gene should not receive an IBA in this situation.
@mugitty mugitty self-assigned this Nov 7, 2019
@dustine32
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Just noting I also have a ticket to handle this in the IBA propagation script:

pantherdb/fullgo_paint_update#39

@mugitty
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mugitty commented Oct 13, 2020

Completed

@mugitty mugitty closed this as completed Oct 13, 2020
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