The readme.md file ([here](https://github.com/stm32duino/Arduino_Core_STM32/blob/master/README.md)) does not list the STM32F446ZE as a supported board. However, 5 months ago this folder was added: https://github.com/stm32duino/Arduino_Core_STM32/tree/2.0.0/variants/STM32F4xx/F446Z(C-E)(H-J-T) I believe this means the F446ZE is supported, but the readme.md file hasn't been updated to show this.