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There has been an error in gunicorn logs coming from the tool predictions API:
From a google search I found recommendations to use
HDF5_USE_FILE_LOCKING: "FALSE"
. Checked out EU and Main infrastructure playbooks and found that they are already using this, and they have adopted it recently. (galaxyproject/usegalaxy-playbook@3724a13#diff-68bca5ccf2e9695dcca9925b36cce7bb8e7bd223d9c6531649be01986c661020R31)I'm not sure if this means instances are individually compensating for something that has gone wrong in Galaxy