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An R package for performing MetaSTAAR procedure in whole-genome sequencing studies

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R build status Build Status Build status License: GPL v3

MetaSTAAR (Meta-analysis of variant-Set Test for Association using Annotation infoRmation)

This is an R package for performing MetaSTAAR procedure in whole-genome sequencing studies.

Description

MetaSTAAR is an R package for performing Meta-analysis of variant-Set Test for Association using Annotation infoRmation (MetaSTAAR) procedure in whole-genome sequencing (WGS) studies.

Workflow Overview

MetaSTAAR_workflow

Prerequisites

R (recommended version >= 3.5.1)

For optimal computational performance, it is recommended to use an R version configured with the Intel Math Kernel Library (or other fast BLAS/LAPACK libraries). See the instructions on building R with Intel MKL.

Dependencies

MetaSTAAR links to R packages Rcpp, RcppArmadillo and STAAR, and also imports R packages Rcpp, STAAR, Matrix, dplyr, expm, MASS. These dependencies should be installed before installing MetaSTAAR.

Installation

library(devtools)
devtools::install_github("xihaoli/MetaSTAAR",ref="main")

Usage

Please see the MetaSTAAR user manual for detailed usage of MetaSTAAR package.

Version

The current version is 0.9.6 (August 3, 2022).

License

This software is licensed under GPLv3.

GPLv3 GNU General Public License, GPLv3