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"max predicate approach" for refactoring "treats" #1328

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merged 42 commits into from
Dec 15, 2023

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@sierra-moxon sierra-moxon commented May 24, 2023

Treats refactoring proposal, summarized here: https://docs.google.com/document/d/1ff_-SYdixIQrPStKkyUeVfMnLHkvuDziCnkTNH-y8-Y/edit#

Contributing members:
Matt Brush @mbrush
Mike Bada @mikebada
Sandrine Muller @sandrine-m
Vlado Dansik @vdancik
Kamileh Narsinh @GitHubbit

and others in the predicates WG.

@sierra-moxon sierra-moxon changed the title draft PR for the "max predicate approach" for refactoring "treats" "max predicate approach" for refactoring "treats" Aug 2, 2023
sierra-moxon and others added 2 commits October 2, 2023 12:02
updating definition of treats to reflect input from recent conversations with KPs/ARAs.
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mbrush commented Dec 8, 2023

I just updated the 'treats' definition to reflect input form recent conversations with KPs/ARAs. If now reads as follows:

  Holds between an intervention (substance, procedure, or activity) and a medical condition
  (disease or phenotypic feature), and states that the intervention is able to ameliorate, 
  stabilize, or cure the condition or delay, prevent, or reduce the risk of it manifesting 
  in the first place. 
  ‘Treats’ edges should be asserted (knowledge_level: assertion) only in cases where there 
  is strong supporting evidence - i.e. the intervention is approved or in phase 4 trials for 
  the condition, or is an otherwise established treatment in the medical community (e.g. widely-
  accepted or formally recommended off-label use). In the absence of such evidence, weaker 
  predicates should be used in asserted edges (e.g. ‘in clinical trials for’ or ‘beneficial 
  in models of’). ‘Treats’ edges based on weaker or indirect forms of evidence can however 
  be created as predictions (knowledge_level: prediction) and should point to the more 
  foundational asserted edges that support them.

My edits introduced back the term 'intervention as subsuming substances, procedures, or activities in the first paragraph. And added the parenthetical "(e.g. widely- accepted or formally recommended off-label use) to the second paragraph - to call out specific example of an established treatment.

mbrush and others added 2 commits December 8, 2023 12:26
@sierra-moxon sierra-moxon merged commit 7dfbba4 into master Dec 15, 2023
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2 participants