Integration of treatment response data in OncoPrint tab

[pvannierop]

What? Why?

This PR will implement handling of the new treatment response (genetic entity) data type by the OncoPrint component (see this backend PR).

Changes

• Treatment response profiles are shown in the heatmap menu (when available in cBioPortal db) (see Fig.1). When a treatment response value is selected, treatments can be added as a heatmap track by pressing the Add Treatments to Heatmap button.
• Treatment data points can be truncated (real value lies beyond a certain value) which can be indicated by > or < prefixes to values. Heatmap track for treatment profiles are represented with a new legend type that shows continuous values (gradient) and truncated values (categories) (see Fig.2). Clustering of treatment heatmap tracks that contain truncated values used the truncated value for respective samples (for example 8 represents truncated value >8).
• Tooltips on a treatment heatmap track contain an url to external websites (when defined in cbioportal db) (see Fig.2).

Notes

• In this PR treatments are entered by typing the stable_id of treatments in the text box in the heatmap menu. A new input menu for treatments that allows users to search for treatments is implemented in a different PR.
• This PR is dependent on an updated version of oncoprintjs (v2.0.0).

Images

Figure 1

1. Treatment profile shown in heatmap menu
2. Button name shows Add Treatments to Heatmap when treatment profile is selected
   

Figure 2

1. Treatment profile shown as heatmap track
2. New legend type with continuous and truncated values
3. URL in tooltip of treatment heatmap tracks