Integration of treatment response data in OncoPrint tab

[pvannierop]

What? Why?

This PR will implement handling of the new treatment response (genetic entity) data type by the OncoPrint component (see this backend PR). The selection of treatments to be shown on the oncoprint does not occur on the Query page but in the heatmap menu. For this reason identifier validation as used for gene names on the query page does not support the user in entering valid identifiers. This PR will improve selection of treatments in the heatmap menu by allowing selection of treatments from a select box and by parsing identifiers typed by the user.

Changes

• Treatment response profiles are shown in the heatmap menu (when available in cBioPortal db) (see Fig.1). When a treatment response value is selected, treatments can be added as a heatmap track by pressing the Add Treatments to Heatmap button.
• Treatment data points can be truncated (real value lies beyond a certain value) which can be indicated by > or < prefixes to values. Heatmap track for treatment profiles are represented with a new legend type that shows continuous values (gradient) and truncated values (categories) (see Fig.2). Clustering of treatment heatmap tracks that contain truncated values used the truncated value for respective samples (for example 8 represents truncated value >8).
• Tooltips on a treatment heatmap track contain an url to external websites (when defined in cbioportal db) (see Fig.2).
• Entries in the treatment select box can be filtered for key-words (looks in stable_id, name and description fields for treatments) (see Fig.3). Individual treatments can be selected with check boxes. All treatments can be (de-)selected using buttons (see Fig.3).
• Selected treatments are displayed in the menu as icons (see Fig.4). Treatments can be removed by pressing the X-button in respective icons.
• Treatment identifiers can be typed in the free text area. Recognized treatments are added as icon above, and selected in the treatment selection menu (see Fig.4).

Notes

• This PR should be merged after this frontend PR.
• A similar menu for genes can be implemented, but is not included in this PR.

Images

Figure 1

• Selection box for treatments is displayed when treatment profile is selected.
  

Figure 2

1. Treatment profile shown as heatmap track
2. New legend type with continuous and truncated values
3. URL in tooltip of treatment heatmap tracks
   

Figure 3

• Filtering of treatments in the selection box
• Selection of treatment via check box
• Buttons for selection and deselection of all treatments
  

Figure 4

• Selected treatments are show as icons
• Icons have a X-button used to remove a selected treatment
• A recognized treatment identifier in the text-area is added as a
  
  

BACKEND_BRANCH=thehyve:treatment_study_implementation_rebased

[adamabeshouse]

please make sure to remove yarn-error.log