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Add protein-translation #957

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10 changes: 9 additions & 1 deletion config.json
Original file line number Diff line number Diff line change
Expand Up @@ -566,6 +566,14 @@
"strings"
]
},
{
"slug": "protein-translation",
"name": "Protein Translation",
"uuid": "f1ad3d6e-7fc2-4461-8ea2-554c2fa9f1f0",
"practices": [],
"prerequisites": [],
"difficulty": 4
},
{
"slug": "meetup",
"name": "Meetup",
Expand Down Expand Up @@ -1026,7 +1034,7 @@
"arrays",
"control_flow_loops",
"strings"
]
]
},
{
"slug": "eliuds-eggs",
Expand Down
45 changes: 45 additions & 0 deletions exercises/practice/protein-translation/.docs/instructions.md
Original file line number Diff line number Diff line change
@@ -0,0 +1,45 @@
# Instructions

Translate RNA sequences into proteins.

RNA can be broken into three nucleotide sequences called codons, and then translated to a polypeptide like so:

RNA: `"AUGUUUUCU"` => translates to

Codons: `"AUG", "UUU", "UCU"`
=> which become a polypeptide with the following sequence =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

There are 64 codons which in turn correspond to 20 amino acids; however, all of the codon sequences and resulting amino acids are not important in this exercise.
If it works for one codon, the program should work for all of them.
However, feel free to expand the list in the test suite to include them all.

There are also three terminating codons (also known as 'STOP' codons); if any of these codons are encountered (by the ribosome), all translation ends and the protein is terminated.

All subsequent codons after are ignored, like this:

RNA: `"AUGUUUUCUUAAAUG"` =>

Codons: `"AUG", "UUU", "UCU", "UAA", "AUG"` =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

Note the stop codon `"UAA"` terminates the translation and the final methionine is not translated into the protein sequence.

Below are the codons and resulting Amino Acids needed for the exercise.

| Codon | Protein |
| :----------------- | :------------ |
| AUG | Methionine |
| UUU, UUC | Phenylalanine |
| UUA, UUG | Leucine |
| UCU, UCC, UCA, UCG | Serine |
| UAU, UAC | Tyrosine |
| UGU, UGC | Cysteine |
| UGG | Tryptophan |
| UAA, UAG, UGA | STOP |

Learn more about [protein translation on Wikipedia][protein-translation].

[protein-translation]: https://en.wikipedia.org/wiki/Translation_(biology)
20 changes: 20 additions & 0 deletions exercises/practice/protein-translation/.meta/config.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,20 @@
{
"authors": [
"ryanplusplus"
],
"files": {
"solution": [
"protein_translation.c",
"protein_translation.h"
],
"test": [
"test_protein_translation.c"
],
"example": [
".meta/example.c",
".meta/example.h"
]
},
"blurb": "Translate RNA sequences into proteins.",
"source": "Tyler Long"
}
62 changes: 62 additions & 0 deletions exercises/practice/protein-translation/.meta/example.c
Original file line number Diff line number Diff line change
@@ -0,0 +1,62 @@
#include <string.h>
#include "protein_translation.h"

enum { codon_length = 3 };

typedef struct {
const char *const codon;
protein_t protein;
bool stop;
} protein_translation_t;

static const protein_translation_t translations[] = {
{ "AUG", Methionine, false },
{ "UUU", Phenylalanine, false },
{ "UUC", Phenylalanine, false },
{ "UUA", Leucine, false },
{ "UUG", Leucine, false },
{ "UCU", Serine, false },
{ "UCC", Serine, false },
{ "UCA", Serine, false },
{ "UCG", Serine, false },
{ "UAU", Tyrosine, false },
{ "UAC", Tyrosine, false },
{ "UGU", Cysteine, false },
{ "UGC", Cysteine, false },
{ "UGG", Tryptophan, false },
{ "UAA", 0, true },
{ "UAG", 0, true },
{ "UGA", 0, true },
};
static const size_t translation_count =
sizeof(translations) / sizeof(translations[0]);

proteins_t proteins(const char *const rna)
{
proteins_t proteins = { .valid = true, .count = 0 };

size_t rna_length = strlen(rna);

for (size_t i = 0; i < rna_length; i += codon_length) {
bool found_codon = false;

for (size_t j = 0; j < translation_count; j++) {
if (strncmp(rna + i, translations[j].codon, codon_length) == 0) {
if (translations[j].stop) {
return proteins;
} else {
proteins.proteins[proteins.count++] = translations[j].protein;
found_codon = true;
break;
}
}
}

if (!found_codon) {
proteins.valid = false;
return proteins;
}
}

return proteins;
}
27 changes: 27 additions & 0 deletions exercises/practice/protein-translation/.meta/example.h
Original file line number Diff line number Diff line change
@@ -0,0 +1,27 @@
#ifndef PROTEIN_TRANSLATION_H
#define PROTEIN_TRANSLATION_H

#include <stdbool.h>
#include <stddef.h>

#define MAX_PROTEINS 10

typedef enum {
Methionine,
Phenylalanine,
Leucine,
Serine,
Tyrosine,
Cysteine,
Tryptophan,
} protein_t;

typedef struct {
bool valid;
size_t count;
protein_t proteins[MAX_PROTEINS];
} proteins_t;

proteins_t proteins(const char *const rna);

#endif
100 changes: 100 additions & 0 deletions exercises/practice/protein-translation/.meta/tests.toml
Original file line number Diff line number Diff line change
@@ -0,0 +1,100 @@
# This is an auto-generated file.
#
# Regenerating this file via `configlet sync` will:
# - Recreate every `description` key/value pair
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion)
# - Preserve any other key/value pair
#
# As user-added comments (using the # character) will be removed when this file
# is regenerated, comments can be added via a `comment` key.

[2c44f7bf-ba20-43f7-a3bf-f2219c0c3f98]
description = "Empty RNA sequence results in no proteins"

[96d3d44f-34a2-4db4-84cd-fff523e069be]
description = "Methionine RNA sequence"

[1b4c56d8-d69f-44eb-be0e-7b17546143d9]
description = "Phenylalanine RNA sequence 1"

[81b53646-bd57-4732-b2cb-6b1880e36d11]
description = "Phenylalanine RNA sequence 2"

[42f69d4f-19d2-4d2c-a8b0-f0ae9ee1b6b4]
description = "Leucine RNA sequence 1"

[ac5edadd-08ed-40a3-b2b9-d82bb50424c4]
description = "Leucine RNA sequence 2"

[8bc36e22-f984-44c3-9f6b-ee5d4e73f120]
description = "Serine RNA sequence 1"

[5c3fa5da-4268-44e5-9f4b-f016ccf90131]
description = "Serine RNA sequence 2"

[00579891-b594-42b4-96dc-7ff8bf519606]
description = "Serine RNA sequence 3"

[08c61c3b-fa34-4950-8c4a-133945570ef6]
description = "Serine RNA sequence 4"

[54e1e7d8-63c0-456d-91d2-062c72f8eef5]
description = "Tyrosine RNA sequence 1"

[47bcfba2-9d72-46ad-bbce-22f7666b7eb1]
description = "Tyrosine RNA sequence 2"

[3a691829-fe72-43a7-8c8e-1bd083163f72]
description = "Cysteine RNA sequence 1"

[1b6f8a26-ca2f-43b8-8262-3ee446021767]
description = "Cysteine RNA sequence 2"

[1e91c1eb-02c0-48a0-9e35-168ad0cb5f39]
description = "Tryptophan RNA sequence"

[e547af0b-aeab-49c7-9f13-801773a73557]
description = "STOP codon RNA sequence 1"

[67640947-ff02-4f23-a2ef-816f8a2ba72e]
description = "STOP codon RNA sequence 2"

[9c2ad527-ebc9-4ace-808b-2b6447cb54cb]
description = "STOP codon RNA sequence 3"

[f4d9d8ee-00a8-47bf-a1e3-1641d4428e54]
description = "Sequence of two protein codons translates into proteins"

[dd22eef3-b4f1-4ad6-bb0b-27093c090a9d]
description = "Sequence of two different protein codons translates into proteins"

[d0f295df-fb70-425c-946c-ec2ec185388e]
description = "Translate RNA strand into correct protein list"

[e30e8505-97ec-4e5f-a73e-5726a1faa1f4]
description = "Translation stops if STOP codon at beginning of sequence"

[5358a20b-6f4c-4893-bce4-f929001710f3]
description = "Translation stops if STOP codon at end of two-codon sequence"

[ba16703a-1a55-482f-bb07-b21eef5093a3]
description = "Translation stops if STOP codon at end of three-codon sequence"

[4089bb5a-d5b4-4e71-b79e-b8d1f14a2911]
description = "Translation stops if STOP codon in middle of three-codon sequence"

[2c2a2a60-401f-4a80-b977-e0715b23b93d]
description = "Translation stops if STOP codon in middle of six-codon sequence"

[1e75ea2a-f907-4994-ae5c-118632a1cb0f]
description = "Non-existing codon can't translate"

[9eac93f3-627a-4c90-8653-6d0a0595bc6f]
description = "Unknown amino acids, not part of a codon, can't translate"

[9d73899f-e68e-4291-b1e2-7bf87c00f024]
description = "Incomplete RNA sequence can't translate"

[43945cf7-9968-402d-ab9f-b8a28750b050]
description = "Incomplete RNA sequence can translate if valid until a STOP codon"
37 changes: 37 additions & 0 deletions exercises/practice/protein-translation/makefile
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@@ -0,0 +1,37 @@
### If you wish to use extra libraries (math.h for instance),
### add their flags here (-lm in our case) in the "LIBS" variable.

LIBS = -lm

###
CFLAGS = -std=c99
CFLAGS += -g
CFLAGS += -Wall
CFLAGS += -Wextra
CFLAGS += -pedantic
CFLAGS += -Werror
CFLAGS += -Wmissing-declarations
CFLAGS += -DUNITY_SUPPORT_64 -DUNITY_OUTPUT_COLOR

ASANFLAGS = -fsanitize=address
ASANFLAGS += -fno-common
ASANFLAGS += -fno-omit-frame-pointer

.PHONY: test
test: tests.out
@./tests.out

.PHONY: memcheck
memcheck: ./*.c ./*.h
@echo Compiling $@
@$(CC) $(ASANFLAGS) $(CFLAGS) test-framework/unity.c ./*.c -o memcheck.out $(LIBS)
@./memcheck.out
@echo "Memory check passed"

.PHONY: clean
clean:
rm -rf *.o *.out *.out.dSYM

tests.out: ./*.c ./*.h
@echo Compiling $@
@$(CC) $(CFLAGS) test-framework/unity.c ./*.c -o tests.out $(LIBS)
Original file line number Diff line number Diff line change
@@ -0,0 +1 @@
#include "protein_translation.h"
27 changes: 27 additions & 0 deletions exercises/practice/protein-translation/protein_translation.h
Original file line number Diff line number Diff line change
@@ -0,0 +1,27 @@
#ifndef PROTEIN_TRANSLATION_H
#define PROTEIN_TRANSLATION_H

#include <stdbool.h>
#include <stddef.h>

#define MAX_PROTEINS 10

typedef enum {
Methionine,
Phenylalanine,
Leucine,
Serine,
Tyrosine,
Cysteine,
Tryptophan,
} protein_t;

typedef struct {
bool valid;
size_t count;
protein_t proteins[MAX_PROTEINS];
} proteins_t;

proteins_t proteins(const char *const rna);

#endif
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