DrugMechDB

Homepage Link: https://github.com/SuLab/DrugMechDB

Description: Most drug mechanisms are described simply as a protein target, or sometimes a pathway, that then treats the disease. However, there are usually more steps across a biological knowledge graph required to traverse from the target through its mechanism to the reduction of a disease. This database attempts to catalog a subset of known drug-disease indications as a path through a network of biomedical entities.

Example edge:

Additional Links:

• https://github.com/SuLab/DrugMechDB
• https://sulab.github.io/DrugMechDB/
• https://www.nature.com/articles/s41597-023-02534-z