[HLS-353] Add utility function docs #12
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Signed-off-by: Karen Feng <karen.feng@databricks.com>
Signed-off-by: Karen Feng <karen.feng@databricks.com>
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# This is the 1st commit message: WIP # This is the commit message projectglow#2: Get jar working Don't use Kryo serializer Don't parallelize un-serializable Hadoop FileStatus Change descrip WIP Whoops bintray Not local Quiet logs Remove tmp file Actually rename bintray Setting version to 0.1.0 WIP WIP License fixup Resolver WIP Change version Setting version to 0.1.1 WIP Setting version to 0.1.2 Setting version to 0.1.3-SNAPSHOT WIP Setting version to 0.1.2 Setting version to 0.1.3-SNAPSHOT Exclude many GATK deps Setting version to 0.1.3 Setting version to 0.1.4-SNAPSHOT Setting version to 0.1.4 Setting version to 0.1.5-SNAPSHOT Whoops Setting version to 0.1.3 Setting version to 0.1.4-SNAPSHOT Setting version to 0.1.4 Setting version to 0.1.5-SNAPSHOT Setting version to 0.1.6 Setting version to 0.1.7-SNAPSHOT Yay deps Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT Setting version to 0.1.8 Setting version to 0.1.9-SNAPSHOT Setting version to 0.1.1 Setting version to 0.1.2-SNAPSHOT Setting version to 0.1.10 Setting version to 0.1.11-SNAPSHOT Setting version to 0.1.15 Setting version to 0.1.16-SNAPSHOT Setting version to 0.1.9 Setting version to 0.1.10-SNAPSHOT WIP Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT Setting version to 0.1.8 Setting version to 0.1.9-SNAPSHOT Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT Add tests back Setting version to 0.1.8 Setting version to 0.1.9-SNAPSHOT Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT Setting version to 0.1.13 Setting version to 0.1.14-SNAPSHOT WIP Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT WIP Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT WIP Setting version to 0.1.8 Setting version to 0.1.9-SNAPSHOT Setting version to 0.1.11 Setting version to 0.1.12-SNAPSHOT Setting version to 0.1.7 Setting version to 0.1.8-SNAPSHOT Exclude findbugs Setting version to 0.1.8 Setting version to 0.1.9-SNAPSHOT WIP Cleanup # This is the commit message projectglow#3: Rename org # This is the commit message projectglow#4: Rename env # This is the commit message projectglow#5: Setting version to 0.1.0 # This is the commit message projectglow#6: Setting version to 0.1.1-SNAPSHOT # This is the commit message projectglow#7: Rename # This is the commit message projectglow#8: Work on test.pypi # This is the commit message projectglow#9: Fix VCFFileWriterSuite (projectglow#63) # This is the commit message projectglow#10: Remove SpecificInternalRow buffer in RowConverter (projectglow#65) * Remove SpecificInternalRow buffer in RowConverter * comment # This is the commit message projectglow#11: Update CircleCI badge # This is the commit message projectglow#12: Move build/test from README to wiki # This is the commit message projectglow#13: More cleanup # This is the commit message projectglow#14: Newline # This is the commit message projectglow#15: address comments # This is the commit message projectglow#16: Circleci fixups # This is the commit message projectglow#17: Un-exclude netlib from gatk # This is the commit message projectglow#18: CircleCI indents # This is the commit message projectglow#19: Change bintray org # This is the commit message projectglow#20: Setting version to 0.1.0 # This is the commit message projectglow#21: Bintray repo # This is the commit message projectglow#22: Move bintrayrepo # This is the commit message projectglow#23: Setting version to 0.1.1-SNAPSHOT
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Looks good. Please merge and I will transfer into my changes and do some minor edits. |
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* Fix Glow tests (#6) * oops * fix pipe transformer cleanup Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Update log4j.properties Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * livehtml Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * fix Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Add license header (#9) Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * add CONTIBURING.md (#10) Signed-off-by: Henry D <henrydavidge@gmail.com> Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * notebook addresses Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * glow to Glow Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * sidebar width Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * utility Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * [HLS-353] Add utility function docs (#12) * Add glue fns Signed-off-by: Karen Feng <karen.feng@databricks.com> * Address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * comments addressed Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com>
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* WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * simplify tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * index map compat Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add more tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * pass args as ints Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't roll our own splitter Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename sample_index to sample_blocks Signed-off-by: Karen Feng <karen.feng@databricks.com>
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Signed-off-by: Henry Davidge <hhd@databricks.com>
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* Add glue fns Signed-off-by: Karen Feng <karen.feng@databricks.com> * Address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> Signed-off-by: Henry Davidge <hhd@databricks.com>
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* Fix Glow tests (projectglow#6) * oops * fix pipe transformer cleanup Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Update log4j.properties Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * livehtml Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * fix Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Add license header (projectglow#9) Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * add CONTIBURING.md (projectglow#10) Signed-off-by: Henry D <henrydavidge@gmail.com> Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * notebook addresses Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * glow to Glow Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * more docs Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * sidebar width Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * utility Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * [HLS-353] Add utility function docs (projectglow#12) * Add glue fns Signed-off-by: Karen Feng <karen.feng@databricks.com> * Address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * comments addressed Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> Signed-off-by: Henry Davidge <hhd@databricks.com>
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* WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * simplify tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * index map compat Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add more tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * pass args as ints Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't roll our own splitter Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename sample_index to sample_blocks Signed-off-by: Karen Feng <karen.feng@databricks.com> Signed-off-by: Henry Davidge <hhd@databricks.com>
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* Add Leland's demo notebook * block_variants_and_samples Transformer to create genotype DataFrame for WGR (#2) * blocks Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test vcf Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * transformer Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * refactor and conform with ridge namings Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test files Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra file Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * sort_key Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * feat: ridge models for wgr added (#1) * feat: ridge models for wgr added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Doc strings added for levels/functions.py Some typos fixed in ridge_model.py Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * ridge_model and RidgeReducer unit tests added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * RidgeRegression unit tests added test data README added ridge_udfs.py docstrings added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Changes made to accessing the sample ID map and more docstrings The map_normal_eqn and score_models functions previously expected the sample IDs for a given sample block to be found in the Pandas DataFrame, which mean we had to join them on before the .groupBy().apply(). These functions now expect the sample block to sample IDs mapping to be provided separately as a dict, so that the join is no longer required. RidgeReducer and RidgeRegression APIs remain unchanged. docstrings have been added for RidgeReducer and RidgeRegression classes. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Refactored object names and comments to reflect new terminology Where 'block' was previously used to refer to the set of columns in a block, we now use 'header_block' Where 'group' was previously used to refer to the set of samples in a block, we now use 'sample_block' Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * [HLS-539] Fix compatibility between blocked GT transformer and WGR (#6) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Spark 3 needs more recent PyArrow, reduce mem consumption by removing unnecessary caching Signed-off-by: Karen Feng <karen.feng@databricks.com> * PyArrow 0.15.1 only with PySpark 3 Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't use toPandas() Signed-off-by: Karen Feng <karen.feng@databricks.com> * Upgrade pyarrow Signed-off-by: Karen Feng <karen.feng@databricks.com> * Only register once Signed-off-by: Karen Feng <karen.feng@databricks.com> * Minimize memory usage Signed-off-by: Karen Feng <karen.feng@databricks.com> * Select before head Signed-off-by: Karen Feng <karen.feng@databricks.com> * set up/tear down Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try limiting pyspark memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * No teardown Signed-off-by: Karen Feng <karen.feng@databricks.com> * Extend timeout Signed-off-by: Karen Feng <karen.feng@databricks.com> * Simplify ordering logic in levels code (#7) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * start changing for readability * use input label ordering * rename create_row_indexer * undo column sort * change reduce Signed-off-by: Henry D <henrydavidge@gmail.com> * further simplify reduce * sorted alpha names * remove ordering * comments Signed-off-by: Henry D <henrydavidge@gmail.com> * Set arrow env var in build Signed-off-by: Henry D <henrydavidge@gmail.com> * faster sort * add test file * undo test data change * >= * formatting * empty Co-authored-by: Karen Feng <karen.feng@databricks.com> * Limit Spark memory conf in tests (#9) * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf transform Signed-off-by: Karen Feng <karen.feng@databricks.com> * Set driver memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try changing spark mem Signed-off-by: Karen Feng <karen.feng@databricks.com> * match java tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * remove driver memory flag Signed-off-by: Karen Feng <karen.feng@databricks.com> * Improve partitioning in block_variants_and_samples transformer (#11) Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Remove unnecessary header_block grouping (#10) * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Create sample ID blocking helper functions (#12) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * simplify tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * index map compat Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add more tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * pass args as ints Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't roll our own splitter Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename sample_index to sample_blocks Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add type-checking to WGR APIs (#14) * Add type-checking to APIs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check valid alphas Signed-off-by: Karen Feng <karen.feng@databricks.com> * check 0 sig Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add to install_requires list Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add covariate support (#13) * Added necessary modifications to accomodate covariates in model fitting. The initial formulation of the WGR model assumed a form y ~ Xb, however in general we would like to use a model of the form y ~ Ca + Xb, where C is some matrix of covariates that are separate from the genomic features X. This PR makes numerous changes to accomodate covariate matrix C. Adding covariates required the following breaking changes to the APIs: * indexdf is now a required argument for RidgeReducer.transform() and RidgeRegression.transform(): * RidgeReducer.transform(blockdf, labeldf, modeldf) -> RidgeReducer.transform(blockdf, labeldf, indexdf, modeldf) * RidgeRegression.transform(blockdf, labeldf, model, cvdf) -> RidgeRegression.transform(blockdf, labeldf, indexdf, model, cvdf) Additionally, the function signatures for the fit and transform methods of RidgeReducer and RidgeRegression have all been updated to accomodate an optional covariate DataFrame as the final argument. Two new tests have been added to test_ridge_regression.py to test run modes with covariates: * test_ridge_reducer_transform_with_cov * test_two_level_regression_with_cov Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Cleaned up one unnecessary Pandas import Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Small changes for clarity and consistence with the rest of the code. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Forgot one usage of coalesce Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Added a couple of comments to explain logic and replaced usages of .values with .array Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Fixed one instance of the change .values -> .array where it was made in error. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Typo in test_ridge_regression.py. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Style auto-updates with yapfAll Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Karen Feng <karen.feng@databricks.com> * Flatten estimated phenotypes (#15) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Order to match labeldf Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check we tie-break Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * test var name Signed-off-by: Karen Feng <karen.feng@databricks.com> * clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add fit_transform function to models (#17) Signed-off-by: Karen Feng <karen.feng@databricks.com> * Rename levels (#20) * Rename levels to wgr Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename test files Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add license headers (#21) * headers * executable * fix template rendering * yapf * add header to template * add header to template Signed-off-by: Henry D <henrydavidge@gmail.com> Co-authored-by: Kiavash Kianfar <kiavash.kianfar@databricks.com> Co-authored-by: Karen Feng <karen.feng@databricks.com> Co-authored-by: Leland <leland.barnard@gmail.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com>
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* Add Leland's demo notebook * block_variants_and_samples Transformer to create genotype DataFrame for WGR (#2) * blocks Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test vcf Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * transformer Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * refactor and conform with ridge namings Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test files Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra file Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * sort_key Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * feat: ridge models for wgr added (#1) * feat: ridge models for wgr added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Doc strings added for levels/functions.py Some typos fixed in ridge_model.py Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * ridge_model and RidgeReducer unit tests added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * RidgeRegression unit tests added test data README added ridge_udfs.py docstrings added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Changes made to accessing the sample ID map and more docstrings The map_normal_eqn and score_models functions previously expected the sample IDs for a given sample block to be found in the Pandas DataFrame, which mean we had to join them on before the .groupBy().apply(). These functions now expect the sample block to sample IDs mapping to be provided separately as a dict, so that the join is no longer required. RidgeReducer and RidgeRegression APIs remain unchanged. docstrings have been added for RidgeReducer and RidgeRegression classes. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Refactored object names and comments to reflect new terminology Where 'block' was previously used to refer to the set of columns in a block, we now use 'header_block' Where 'group' was previously used to refer to the set of samples in a block, we now use 'sample_block' Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * [HLS-539] Fix compatibility between blocked GT transformer and WGR (#6) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Spark 3 needs more recent PyArrow, reduce mem consumption by removing unnecessary caching Signed-off-by: Karen Feng <karen.feng@databricks.com> * PyArrow 0.15.1 only with PySpark 3 Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't use toPandas() Signed-off-by: Karen Feng <karen.feng@databricks.com> * Upgrade pyarrow Signed-off-by: Karen Feng <karen.feng@databricks.com> * Only register once Signed-off-by: Karen Feng <karen.feng@databricks.com> * Minimize memory usage Signed-off-by: Karen Feng <karen.feng@databricks.com> * Select before head Signed-off-by: Karen Feng <karen.feng@databricks.com> * set up/tear down Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try limiting pyspark memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * No teardown Signed-off-by: Karen Feng <karen.feng@databricks.com> * Extend timeout Signed-off-by: Karen Feng <karen.feng@databricks.com> * Simplify ordering logic in levels code (#7) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * start changing for readability * use input label ordering * rename create_row_indexer * undo column sort * change reduce Signed-off-by: Henry D <henrydavidge@gmail.com> * further simplify reduce * sorted alpha names * remove ordering * comments Signed-off-by: Henry D <henrydavidge@gmail.com> * Set arrow env var in build Signed-off-by: Henry D <henrydavidge@gmail.com> * faster sort * add test file * undo test data change * >= * formatting * empty Co-authored-by: Karen Feng <karen.feng@databricks.com> * Limit Spark memory conf in tests (#9) * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf transform Signed-off-by: Karen Feng <karen.feng@databricks.com> * Set driver memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try changing spark mem Signed-off-by: Karen Feng <karen.feng@databricks.com> * match java tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * remove driver memory flag Signed-off-by: Karen Feng <karen.feng@databricks.com> * Improve partitioning in block_variants_and_samples transformer (#11) Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Remove unnecessary header_block grouping (#10) * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Create sample ID blocking helper functions (#12) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * simplify tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * index map compat Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add more tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * pass args as ints Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't roll our own splitter Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename sample_index to sample_blocks Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add type-checking to WGR APIs (#14) * Add type-checking to APIs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check valid alphas Signed-off-by: Karen Feng <karen.feng@databricks.com> * check 0 sig Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add to install_requires list Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add covariate support (#13) * Added necessary modifications to accomodate covariates in model fitting. The initial formulation of the WGR model assumed a form y ~ Xb, however in general we would like to use a model of the form y ~ Ca + Xb, where C is some matrix of covariates that are separate from the genomic features X. This PR makes numerous changes to accomodate covariate matrix C. Adding covariates required the following breaking changes to the APIs: * indexdf is now a required argument for RidgeReducer.transform() and RidgeRegression.transform(): * RidgeReducer.transform(blockdf, labeldf, modeldf) -> RidgeReducer.transform(blockdf, labeldf, indexdf, modeldf) * RidgeRegression.transform(blockdf, labeldf, model, cvdf) -> RidgeRegression.transform(blockdf, labeldf, indexdf, model, cvdf) Additionally, the function signatures for the fit and transform methods of RidgeReducer and RidgeRegression have all been updated to accomodate an optional covariate DataFrame as the final argument. Two new tests have been added to test_ridge_regression.py to test run modes with covariates: * test_ridge_reducer_transform_with_cov * test_two_level_regression_with_cov Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Cleaned up one unnecessary Pandas import Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Small changes for clarity and consistence with the rest of the code. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Forgot one usage of coalesce Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Added a couple of comments to explain logic and replaced usages of .values with .array Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Fixed one instance of the change .values -> .array where it was made in error. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Typo in test_ridge_regression.py. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Style auto-updates with yapfAll Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Karen Feng <karen.feng@databricks.com> * Flatten estimated phenotypes (#15) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Order to match labeldf Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check we tie-break Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * test var name Signed-off-by: Karen Feng <karen.feng@databricks.com> * clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add fit_transform function to models (#17) Signed-off-by: Karen Feng <karen.feng@databricks.com> * support alpha inference Signed-off-by: Karen Feng <karen.feng@databricks.com> * test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * more test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * test fixups Signed-off-by: Karen Feng <karen.feng@databricks.com> * sub-sample Signed-off-by: Karen Feng <karen.feng@databricks.com> * test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * address comments - only infer alphas during fit Signed-off-by: Karen Feng <karen.feng@databricks.com> * exception varies Signed-off-by: Karen Feng <karen.feng@databricks.com> * Rename levels (#20) * Rename levels to wgr Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename test files Signed-off-by: Karen Feng <karen.feng@databricks.com> * Errors vary by Spark version Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add license headers (#21) * headers * executable * fix template rendering * yapf Co-authored-by: Kiavash Kianfar <kiavash.kianfar@databricks.com> Co-authored-by: Karen Feng <karen.feng@databricks.com> Co-authored-by: Leland <leland.barnard@gmail.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com>
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* Add Leland's demo notebook * block_variants_and_samples Transformer to create genotype DataFrame for WGR (#2) * blocks Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test vcf Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * transformer Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * refactor and conform with ridge namings Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * test files Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * remove extra file Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * sort_key Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * feat: ridge models for wgr added (#1) * feat: ridge models for wgr added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Doc strings added for levels/functions.py Some typos fixed in ridge_model.py Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * ridge_model and RidgeReducer unit tests added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * RidgeRegression unit tests added test data README added ridge_udfs.py docstrings added Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Changes made to accessing the sample ID map and more docstrings The map_normal_eqn and score_models functions previously expected the sample IDs for a given sample block to be found in the Pandas DataFrame, which mean we had to join them on before the .groupBy().apply(). These functions now expect the sample block to sample IDs mapping to be provided separately as a dict, so that the join is no longer required. RidgeReducer and RidgeRegression APIs remain unchanged. docstrings have been added for RidgeReducer and RidgeRegression classes. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Refactored object names and comments to reflect new terminology Where 'block' was previously used to refer to the set of columns in a block, we now use 'header_block' Where 'group' was previously used to refer to the set of samples in a block, we now use 'sample_block' Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * [HLS-539] Fix compatibility between blocked GT transformer and WGR (#6) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Test fixup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Spark 3 needs more recent PyArrow, reduce mem consumption by removing unnecessary caching Signed-off-by: Karen Feng <karen.feng@databricks.com> * PyArrow 0.15.1 only with PySpark 3 Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't use toPandas() Signed-off-by: Karen Feng <karen.feng@databricks.com> * Upgrade pyarrow Signed-off-by: Karen Feng <karen.feng@databricks.com> * Only register once Signed-off-by: Karen Feng <karen.feng@databricks.com> * Minimize memory usage Signed-off-by: Karen Feng <karen.feng@databricks.com> * Select before head Signed-off-by: Karen Feng <karen.feng@databricks.com> * set up/tear down Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try limiting pyspark memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * No teardown Signed-off-by: Karen Feng <karen.feng@databricks.com> * Extend timeout Signed-off-by: Karen Feng <karen.feng@databricks.com> * Simplify ordering logic in levels code (#7) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * existing tests pass Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename file Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add compat test Signed-off-by: Karen Feng <karen.feng@databricks.com> * scalafmt Signed-off-by: Karen Feng <karen.feng@databricks.com> * collect minimal columns Signed-off-by: Karen Feng <karen.feng@databricks.com> * start changing for readability * use input label ordering * rename create_row_indexer * undo column sort * change reduce Signed-off-by: Henry D <henrydavidge@gmail.com> * further simplify reduce * sorted alpha names * remove ordering * comments Signed-off-by: Henry D <henrydavidge@gmail.com> * Set arrow env var in build Signed-off-by: Henry D <henrydavidge@gmail.com> * faster sort * add test file * undo test data change * >= * formatting * empty Co-authored-by: Karen Feng <karen.feng@databricks.com> * Limit Spark memory conf in tests (#9) * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf transform Signed-off-by: Karen Feng <karen.feng@databricks.com> * Set driver memory Signed-off-by: Karen Feng <karen.feng@databricks.com> * Try changing spark mem Signed-off-by: Karen Feng <karen.feng@databricks.com> * match java tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * remove driver memory flag Signed-off-by: Karen Feng <karen.feng@databricks.com> * Improve partitioning in block_variants_and_samples transformer (#11) Signed-off-by: kianfar77 <kiavash.kianfar@databricks.com> * Remove unnecessary header_block grouping (#10) * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Create sample ID blocking helper functions (#12) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * whoops Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * simplify tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * yapf Signed-off-by: Karen Feng <karen.feng@databricks.com> * index map compat Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add more tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * pass args as ints Signed-off-by: Karen Feng <karen.feng@databricks.com> * Don't roll our own splitter Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename sample_index to sample_blocks Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add type-checking to WGR APIs (#14) * Add type-checking to APIs Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check valid alphas Signed-off-by: Karen Feng <karen.feng@databricks.com> * check 0 sig Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add to install_requires list Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add covariate support (#13) * Added necessary modifications to accomodate covariates in model fitting. The initial formulation of the WGR model assumed a form y ~ Xb, however in general we would like to use a model of the form y ~ Ca + Xb, where C is some matrix of covariates that are separate from the genomic features X. This PR makes numerous changes to accomodate covariate matrix C. Adding covariates required the following breaking changes to the APIs: * indexdf is now a required argument for RidgeReducer.transform() and RidgeRegression.transform(): * RidgeReducer.transform(blockdf, labeldf, modeldf) -> RidgeReducer.transform(blockdf, labeldf, indexdf, modeldf) * RidgeRegression.transform(blockdf, labeldf, model, cvdf) -> RidgeRegression.transform(blockdf, labeldf, indexdf, model, cvdf) Additionally, the function signatures for the fit and transform methods of RidgeReducer and RidgeRegression have all been updated to accomodate an optional covariate DataFrame as the final argument. Two new tests have been added to test_ridge_regression.py to test run modes with covariates: * test_ridge_reducer_transform_with_cov * test_two_level_regression_with_cov Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Cleaned up one unnecessary Pandas import Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Small changes for clarity and consistence with the rest of the code. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Forgot one usage of coalesce Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Added a couple of comments to explain logic and replaced usages of .values with .array Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Fixed one instance of the change .values -> .array where it was made in error. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Typo in test_ridge_regression.py. Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> * Style auto-updates with yapfAll Signed-off-by: Leland Barnard (leland.barnard@gmail.com) Signed-off-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com> Co-authored-by: Karen Feng <karen.feng@databricks.com> * Flatten estimated phenotypes (#15) * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Order to match labeldf Signed-off-by: Karen Feng <karen.feng@databricks.com> * Check we tie-break Signed-off-by: Karen Feng <karen.feng@databricks.com> * cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * test var name Signed-off-by: Karen Feng <karen.feng@databricks.com> * clean up tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * Clean up docs Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * remove accidental files Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add fit_transform function to models (#17) Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * Rename levels (#20) * Rename levels to wgr Signed-off-by: Karen Feng <karen.feng@databricks.com> * rename test files Signed-off-by: Karen Feng <karen.feng@databricks.com> * Add license headers (#21) * headers * executable * fix template rendering * yapf * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * WIP Signed-off-by: Karen Feng <karen.feng@databricks.com> * More work Signed-off-by: Karen Feng <karen.feng@databricks.com> * More cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * Fix docs tests Signed-off-by: Karen Feng <karen.feng@databricks.com> * address comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * fix regression fit description Signed-off-by: Karen Feng <karen.feng@databricks.com> * fix capitalization Signed-off-by: Karen Feng <karen.feng@databricks.com> * address some comments Signed-off-by: Karen Feng <karen.feng@databricks.com> * more cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * More cleanup Signed-off-by: Karen Feng <karen.feng@databricks.com> * add notebook Signed-off-by: Karen Feng <karen.feng@databricks.com> * update notebook Signed-off-by: Karen Feng <karen.feng@databricks.com> Co-authored-by: Henry D <henrydavidge@gmail.com> Co-authored-by: Kiavash Kianfar <kiavash.kianfar@databricks.com> Co-authored-by: Leland <leland.barnard@gmail.com> Co-authored-by: Leland Barnard <leland.barnard@regeneron.com>
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Glue function docs:
How is this patch tested?