OSM Public Strategy Meeting July 2018

[mattodd]

Update: Meeting time: Thursday July 5th. Sydney time 6pm,
Location: http://webconf.ucc.usyd.edu.au/osm-5july2018/ (Join as guest. Probably requires Adobe Flash, so you might want to click on the link a little in advance of the meeting in case of software SNAFU)
The meeting will be recorded and posted online.
Please mute microphone when not speaking.

Hi all. High time we had another online OSM meeting. I'd really like to do this next week if people are amenable.

It'd be very good to review the latest potency and metabolic data, and plan. The plan needs to cover the next 2 months, during which I'll be largely out of action since I'm on a 2-month vacation between leaving Sydney Uni and starting in London. During that time @edwintse @maratsydney @mbhebhe @david1597 will be working as normal in Sydney (though @david1597's position comes to an end towards the end of July.

Lots to do at the moment. I'll gradually assemble an agenda below and will adapt it to any comments.

Timing: Sydney 6pm is EU early morning, which is quite good. Can I suggest Thursday July 5th? Here's the timezone comparison, also shown below:

It'd be nice to have one-slide updates from anyone who wants to speak, BUT: Duration: 1 hour, ideally, so preliminary discussion can always happen here.

Platform: I've been impressed by Zoom, but meetings are limited to 40 mins on their free plan. Difficult to justify paying when I can use Adobe Connect for free via Sydney Uni. Will post the meeting room link here when we've decided on a time. Update: link posted above.

AGENDA

1. Review of the OHOH compound (David)
2. Review of recent potency data (Ed)
3. Review of recent synthetic chemistry and telesubstitution results (Marat)
4. Review of new metabolic data (Mat)
5. Resulting priority actions for Series 4 in July and August (Mat)
6. Actions towards completion of OSM Series 4 Paper 1 (Mat)
7. Review and priority actions for Series 3 (Tha)
8. Status and next steps of pharmacophore competition Part 2 (Mat)
   (Other people who want to speak to one slide - please comment below and I'll insert you - @mcoster @holeung etc etc?)
9. AOB
10. Action Items

[drc007]

OK with me, Chris

…

On 27 Jun 2018, at 14:30, Mat Todd ***@***.***> wrote: Hi all. High time we had another online OSM meeting. I'd really like to do this next week if people are amenable. It'd be very good to review the latest potency and metabolic data, and plan. The plan needs to cover the next 2 months, during which I'll be largely out of action since I'm on a 2-month vacation between leaving Sydney Uni and starting in London. During that time @edwintse <https://github.com/edwintse> @maratsydney <https://github.com/maratsydney> @mbhebhe <https://github.com/mbhebhe> @david1597 <https://github.com/david1597> will be working as normal in Sydney (though @david1597 <https://github.com/david1597>'s position comes to an end towards the end of July. Lots to do at the moment. I'll gradually assemble an agenda below and will adapt it to any comments. Timing: Sydney 6pm is EU early morning, which is quite good. Can I suggest Thursday July 5th? Here <https://www.timeanddate.com/worldclock/meetingtime.html?iso=20180705&p1=224&p2=250&p3=136&p4=87&p5=176&p6=240>'s the timezone comparison. It'd be nice to have one-slide updates from anyone who wants to speak, BUT: Duration: 1 hour, ideally, so preliminary discussion can always happen here. Platform: I've been impressed by Zoom <https://zoom.us/>, but meetings are limited to 40 mins on their free plan. Difficult to justify paying when I can use Adobe Connect for free via Sydney Uni. Will post the meeting room link here when we've decided on a time. AGENDA Review of the OHOH compound (David) Review of recent potency data (Ed) Review of recent synthetic chemistry and telesubstitution results (Marat) Review of new metabolic data (Mat) Resulting priority actions for Series 4 in July and August (Mat) Actions towards completion of OSM Series 4 Paper 1 (Mat) Review and priority actions for Series 3 (Tha) Status and next steps of pharmacophore competition Part 2 (Mat) (Other people who want to speak to one slide - please comment below and I'll insert you - @mcoster <https://github.com/mcoster> @holeung <https://github.com/holeung> etc etc?) X) AOB — You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub <#568>, or mute the thread <https://github.com/notifications/unsubscribe-auth/AGwKRLCPdQ8g9JMYsz71IsQVGx12hUfwks5uA4jwgaJpZM4U5uA8>.

[MedChemProf]

It will be a 4am meeting for me, but I am fine with that. Important we meet.

[MFernflower]

6pm Sydney time is a bit rough for me but I will attempt to set reminders on my phone as this is a super important meeting! @mattodd I wish you the best of luck on the lab move!

[holeung]

I can make it. I can provide 1-2 slides.

[drc007]

@mattodd Are you compiling the slide deck?

[david1597]

@drc007 Yes. Anyone who'd like to speak - please send your single slide to @mattodd.

[mattodd]

Draft 1 of the slide deck is linked below. I'll generate v2 in about 12 hours when I've remaining inputs and am more awake. Note everyone: the URL you'll need for the meeting, up top of the page.
@MedChemProf did you have a slide I can add?
Anyone else? Please remember we only have an hour this time, and there's too much going on to fit into that time, so we need to be brief and selective. I'd like to focus on action items for the next 2 months as the top priority.

OSM Meeting July 2018 v1.pptx

[MedChemProf]

@mattodd I will be in attendance, but no slide input. Summer research students did not materialize, so synthesis of new targets not started. Additional manpower will be following late summer, early fall.

[mcoster]

Sorry I can't make it! School holiday duties... Here's is a very quick, rushed slide with our current efforts. Hope it goes well!

OSM.Meeting.July.2018_COSTER.pptx

[mattodd]

Updated deck, now v2. Happy to take suggestions/additions right up until meeting time, in about 4 hours.

OSM Meeting July 2018 v2.pptx

[MFernflower]

@mattodd @mbhebhe Dont know if this is worthy for inclusion but this was my proposed S3 class compound that would more than likely just target CA - no clue if it's worth making

Also included is a diamino S3 compound designed to look more ATP like

[david1597]

There was a question during the meeting about which species were used for the Pfizer biosynthesis. I forgot who asked - sorry. Initial tests used ten different batches from various species and four cytosols. Various species of liver microsomes gave the conversion, no conversion seen in cytosol. For the scaled-up biosynthesis that produced the samples which were sent for potency testing - it was dog liver microsomes. It was the exact same batch of dog liver microsomes used in both of the experiments that were sent for testing.

[cdsouthan]

May have been mentioned (but I was at WCP2018 Kyoto) but, pending minutes I guess testing a set of front-runners (as diverse as we may have) against the NITD609-RDd2 PfATP4 mutant and wild-type comes pretty high. Maybe Kirk lab could do this for us?

N.b. the PubChem IDs for the top-9 MMVs are here http://www.citeulike.org/user/cdsouthan/article/14611970